Related Experiment Video
Updated: Nov 11, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.9K
Anaplastic thyroid carcinoma with leucocytosis.
Shagufta Naeem1, Anila Riyaz1, Shabana Naz1
1Department of Pathology, Ayub Medical College, Abbottabad, Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|March 23, 2021
Summary
Anaplastic thyroid carcinoma, a rare aggressive cancer, often presents with neutrophilia (elevated neutrophils) and fever. Prompt investigation of these symptoms in patients with long-standing goiter is crucial for early diagnosis and improved outcomes.
Area of Science:
- Oncology
- Pathology
- Hematology
Background:
- Anaplastic thyroid carcinoma (ATC) is an aggressive thyroid malignancy with a poor prognosis.
- Cytological diagnosis is common for ATC, often accompanied by elevated neutrophils in specimens and blood.
- Neutrophilia and fever are potential clinical indicators in ATC.
Purpose of the Study:
- To determine the frequency of neutrophilia with fever in anaplastic thyroid carcinoma.
- To investigate the clinical presentation of ATC, focusing on inflammatory markers.
Main Methods:
- A descriptive cross-sectional study was conducted.
- Included cases diagnosed with ATC via cytology.
- Histopathological examination was performed on a subset of cases.
- Data collected from October 2016 to October 2019.
Main Results:
- Nine out of 150 thyroid cytology cases were diagnosed as ATC.
- All ATC cases showed increased neutrophils on cytology; four cases exhibited leukocytosis.
- Common symptoms included rapidly growing neck mass, weight loss, and hoarseness of voice.
- Five cases were confirmed histopathologically; three patients died within one month.
Conclusions:
- Rapidly enlarging goiter with fever and leukocytosis in patients with long-standing goiter suggests ATC.
- Prompt investigation is recommended for suspected cases of anaplastic thyroid carcinoma.
- Neutrophilia may serve as an important diagnostic clue for ATC.
Related Concept Videos
01:27Disorders of Leukocytes
1.5K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.5K
01:23The Thyroid Gland
5.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
5.4K