[Carotid stenosis in elderly patients]
1Service de neurologie et unité neurovasculaire, centre hospitalier Sainte-Anne, 75674 Paris Cedex 14, France. d.calvet@ch-sainte-anne.fr
Insights
Carotid stenosis increases stroke risk, especially in older adults. Carotid endarterectomy benefits selected symptomatic patients, while its use in asymptomatic cases remains debated due to improved medical treatments.
Area of Science:
- Vascular Neurology
- Geriatric Medicine
- Cardiovascular Surgery
Context:
- Carotid stenosis is a common condition in the elderly.
- It significantly elevates the risk of ischemic stroke and other vascular events.
- Effective management strategies are crucial for preventing cerebrovascular and non-neurological vascular events.
Purpose:
- To review the risk factors and predictive elements of stroke in carotid stenosis.
- To discuss the current recommendations for carotid endarterectomy (CEA) in symptomatic and asymptomatic patients.
- To highlight the evolving role of medical therapy in managing carotid stenosis.
Summary:
- High-grade carotid stenosis (70-99%) with symptoms warrants consideration for CEA.
- Moderate symptomatic stenosis (50-69%) requires careful patient selection, favoring males aged 75+ undergoing early intervention.
- The benefit of CEA for asymptomatic carotid stenosis is debated, with medical therapy advancements reducing stroke risk in non-operated patients.
Impact:
- Optimizing vascular risk factor treatment and antiplatelet therapy are key preventive measures.
- Patient selection for CEA should consider comorbidities, life expectancy, and age, especially in asymptomatic cases.
- Advances in medical management are reshaping the treatment landscape for carotid stenosis, impacting surgical decision-making.
Abstract:
Carotid stenosis -- a frequent finding in elderly patients -- is associated with an increase risk not only of ipsilateral ischemic stroke, but also of cerebrovascular events in other territories and non neurological vascular events. Prevention of those vascular events is mainly based on optimization of vascular risk factor treatment and antiplatelet therapy. The risk of ipsilateral stroke depends on several predictive factors but the main predictors are a previous ischemic stroke in the carotid stenosis territory and the degree of carotid stenosis. It is recommended that patients who experience non disabling ischemic stroke or transient ischemic attack related to a 70 to 99% carotid stenosis should undergo carotid endarterectomy In patients with moderate symptomatic stenosis (between 50 to 69%), the decision to operate is more difficut because the benefit of carotid endarterectomy is less important. Males, 75 year-old and older are more likely to benefit, particularly when carotid endarterectomy is performed within 2 weeks of the symptoms. In patients with asymptomatic stenosis, the benefit of carotid endarterectomy is highly debated, in particular because the risk of stroke in non-operated patients has fallen over the last decades due to advances in medical therapy Selection of asymptomatic patients for carotid endarterectomy should be guided by an assessment of several factors including comorbid conditions, life expectancy, and age.
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