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Published on: February 28, 2019
Sinonasal NK/T-cell lymphoma
M Hmidi1, M Kettani, A Elboukhari
1Service ORL et chirurgie cervico-faciale, hôpital militaire My Ismaïl, boulevard El Hanssali, Meknès, Morocco. mounirhmidi@hotmail.com
Introduction:
Nasal NK/T-cell lymphoma is a rare but well-known clinical entity. Thanks to improvements in anatomopathology and the development of routine immunohistochemistry, the diagnosis of nasal NK/T-cell lymphoma (NK for "natural killer") was recognized by the WHO in 2001. The main differential diagnosis is with Wegener's granulomatosis. Treatment is based on radiotherapy and chemotherapy. Prognosis is poor, with variable evolution and sometimes rapid progression.
Case Report:
The authors report the case of a 54-year-old man without known pathological history, who presented with bilateral nasal obstruction with purulent rhinorrhea. Diagnosis was made on the basis of immunohistochemical study of biopsy samples. The tumor was graded IE on the Ann Arbor classification. Treatment, comprising CHOP chemotherapy followed by radiotherapy, achieved total remission at 8 months' follow-up.
Discussion/Conclusion:
Sinonasal NK/T-cell lymphoma is rare. Diagnosis is based on immunophenotypic and molecular characteristics. It is an aggressive lymphoma, requiring multidisciplinary management. Prognosis is poor.
