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Related Concept Videos

Adrenergic Agonists: Mixed-Action Agents01:28

Adrenergic Agonists: Mixed-Action Agents

Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
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Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
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Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Exercise and Muscle Performance01:27

Exercise and Muscle Performance

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Endurance exercises
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Related Experiment Video

Updated: May 15, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Pseudoephedrine and preexercise feeding: influence on performance.

Kellie R Pritchard-Peschek1, Mark A Osborne, Gary J Slater

  • 1School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia. pritchardkellie@gmail.com

Medicine and Science in Sports and Exercise
|January 1, 2013
PubMed
Summary

Pseudoephedrine (PSE) supplementation did not enhance cycling performance, regardless of pre-exercise food intake. However, PSE intake resulted in urinary concentrations exceeding the World Anti-Doping Agency (WADA) threshold, posing a risk for athletes.

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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Related Experiment Videos

Last Updated: May 15, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Area of Science:

  • Exercise Physiology
  • Sports Science
  • Pharmacology

Background:

  • Understanding the ergogenic potential of common substances like pseudoephedrine (PSE) is crucial for athletes.
  • Investigating the impact of food intake on drug pharmacokinetics and performance is essential for anti-doping and sports science.
  • The World Anti-Doping Agency (WADA) sets thresholds for prohibited substances to ensure fair play.

Purpose of the Study:

  • To determine if pre-exercise food intake affects plasma pseudoephedrine (PSE) concentrations during high-intensity exercise.
  • To evaluate the impact of PSE supplementation on cycling time trial performance.
  • To compare urinary PSE concentrations with WADA's established threshold for doping control.

Main Methods:

  • Ten elite male cyclists/triathletes completed four cycling time trials under fed/nonfed conditions, receiving PSE or placebo.
  • Plasma PSE, catecholamines, and blood lactate were measured at various time points.
  • Urine samples were collected to analyze PSE concentrations against WADA standards.

Main Results:

  • Pseudoephedrine (PSE) supplementation did not significantly improve cycling time trial performance.
  • Fed conditions led to lower plasma PSE concentrations compared to nonfed conditions.
  • Urinary PSE concentrations consistently exceeded the WADA threshold, irrespective of food intake.

Conclusions:

  • Pseudoephedrine (PSE) does not enhance performance in approximately 30-minute cycling time trials.
  • PSE intake, even with food, results in urinary concentrations above WADA's detection limit.
  • Athletes using PSE risk testing positive for doping, regardless of pre-exercise nutrition.