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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Cord IgE and ECP levels of Malay neonates
1Department of Pediatric Pulmonary, University of Texas Health Science, Houston Medical School, Houston, Texas, USA; Department of Molecular Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Background:
Cord IgE and ECP levels are major atopic markers implicated in early childhood allergy development. Most epidemiological studies to date have not utilised current technology to establish baseline cord IgE levels, further aggravated by lack of data in this region. This study also attempts to identify a relationship between cord IgE and ECP levels as a mean to improve sensitivity for early prediction of atopy.
Methods:
A total of 3183 cord blood IgE including 44 cord ECP samples of term neonates from Malay parentage were recruited. Total IgE and ECP levels were determined by ImmunoCAP and fluoroimmunoenzymatic, respectively.
Results:
Cord IgE geometric mean was 0.15 kU/L. Males had higher IgE geometric mean than females (0.17 vs. 0.13). IgE values between 17 pair of twins was not significant (p=0.169). Frequency of males (29.9%) in >0.9 kU/L IgE category was higher than females (26.1%). In the <0.35 kU/L category, females had a higher frequency (44.8%) than males (39.1%). Males had significantly (p=0.023) higher IgE level than females. November and February had the highest mean and median cord IgE level whereas October and December were the lowest, respectively. IgE level across months was not significant (p=0.234). Cord ECP mean was 5.21 g/L and median was 3.75 μg/L. There was no significant correlation (p=0.513; r=-0.101) between cord blood ECP and IgE levels.
Conclusion:
Cord blood IgE level of Malay male neonates was significantly higher than females. These results do not support cord ECP as plausible adjunct parameter to IgE for early atopic detection.
