Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.2K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.2K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Multiple Allele Traits01:49

Multiple Allele Traits

37.9K
The Concept of Multiple Allelism
37.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Omics Analysis Defines Endotypes and Systemic Inflammation in Primary Ciliary Dyskinesia: A Comparison with Healthy Controls.

Annals of the American Thoracic Society·2026
Same author

Challenges faced by women and girls with hemophilia/Carriers: an expert call for closing the diagnosis gap.

Expert review of hematology·2026
Same author

Developing a Measure of Relational Outcomes Between Families and Pediatric Complex Care Programs.

Hospital pediatrics·2026
Same author

Ventilation-perfusion Scan: A Functional Imaging Approach to Regional Lung Disease in Primary Ciliary Dyskinesia.

The open respiratory medicine journal·2026
Same author

Cilia Dynamics in Primary Ciliary Dyskinesia: A Biophysical Characterization of the <i>RSPH4A</i> Founder Variant.

Cells·2026
Same author

Dapsone response in immune thrombocytopenic purpura is associated with dapsone dose and mediated through reduction in haemoglobin: A longitudinal data analysis of 58 adult and paediatric ITP patients demonstrates efficacy and safety.

British journal of haematology·2026

Related Experiment Video

Updated: Jan 13, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.8K

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study.

Suhei C Zuleta De Bernardis1, Okeleji Olayinka1, Mariam Z Quraishi1

  • 1Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth Houston), Houston, Texas, USA.

Pediatric Blood & Cancer
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Sickle cell disease (SCD) significantly increases asthma risk in children, even after accounting for family history. Regular screening for asthma is crucial in children with SCD due to the age-related rise in prevalence.

Keywords:
asthmaepidemiologyscreeningsickle cell disease

More Related Videos

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

28.5K
Quality-Controlled Sputum Analysis by Flow Cytometry
07:22

Quality-Controlled Sputum Analysis by Flow Cytometry

Published on: August 9, 2021

5.8K

Related Experiment Videos

Last Updated: Jan 13, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.8K
Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

28.5K
Quality-Controlled Sputum Analysis by Flow Cytometry
07:22

Quality-Controlled Sputum Analysis by Flow Cytometry

Published on: August 9, 2021

5.8K

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Genetics

Background:

  • Sickle cell disease (SCD) and asthma share overlapping symptoms, making it difficult to determine if SCD increases asthma risk.
  • Asthma prevalence in children with SCD is thought to be similar to or higher than in the general population.

Purpose of the Study:

  • To clarify the association between sickle cell disease and asthma risk.
  • To assess asthma risk in children with SCD compared to their siblings, controlling for familial and environmental factors.

Main Methods:

  • A prospective, case-control sibling comparison study.
  • Included 248 children with SCD and 328 siblings aged 2-18 years.
  • Asthma diagnosis confirmed by pediatric pulmonologist clinical assessment.

Main Results:

  • Asthma prevalence was significantly higher in children with SCD (28.6%) compared to siblings (7.6%).
  • SCD status was the sole factor associated with increased asthma odds (OR: 7.57) after adjusting for age and sex.
  • In the SCD group, risk factors included age, male sex, family history of asthma, and hydroxyurea use.

Conclusions:

  • Sickle cell disease independently increases asthma risk, irrespective of familial and environmental influences.
  • The rising prevalence of asthma with age in children with SCD underscores the need for routine screening.