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Decreased serum paraoxonase activity in patients with chronic pancreatitis
1Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, P.R. China.
Background:
Recent evidences suggest that oxidative stress is involved in the mechanism of chronic pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of our study is to investigate whether serum PON1 activity is associated with the presence of CP.
Methods:
A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in this study. Serum PON1 activity was measured using paraoxon as a substrate.
Results:
Serum PON1 activity was significantly decreased in CP patients compared with healthy subjects. Multivariable logistic regression analysis revealed that serum PON1 activity was a determinant of the presence of CP (OR = 0.992, 95% CI = 0.987-0.998; P = 0.006).
Conclusions:
Decreased serum PON1 activity may be considered as a predicting marker of the presence of CP.
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