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Related Experiment Video

Updated: May 15, 2026

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure

Published on: May 27, 2022

Aspergillus--classification and antifungal susceptibilities.

Walter Buzina¹

¹Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Graz, Austria. walter.buzina@medunigraz.at

Current Pharmaceutical Design

|January 3, 2013

Summary

Aspergillus fungi have significant industrial, food spoilage, and medical impacts. Most known species cause infections, and all tested Aspergillus are resistant to fluconazole and 5-fluorocytosine.

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Area of Science:

Medical Mycology
Fungal Genetics
Antimicrobial Resistance

Background:

The fungal genus Aspergillus holds significant importance for humans, encompassing industrial applications, food spoilage, and a wide range of diseases.
Hundreds of Aspergillus species are known, with nearly fifty capable of causing infections in humans and animals.
Recent taxonomic revisions have classified the genus Aspergillus into 8 subgenera and 22 sections.

Purpose of the Study:

To review the spectrum of diseases caused by Aspergillus species.
To discuss the antifungal susceptibility profiles of Aspergillus species against currently available antifungals.

Main Methods:

Literature review of Aspergillus-related diseases.
Analysis of antifungal susceptibility data for various Aspergillus species.

Main Results:

Aspergillus infections range from superficial cutaneous to invasive and systemic forms.
All investigated Aspergillus species exhibit resistance to fluconazole and 5-fluorocytosine.
The paper details the susceptibility of Aspergillus to a broader range of antifungals.

Conclusions:

Aspergillus poses a significant threat due to its diverse pathogenic potential.
Established antifungal treatments like fluconazole and 5-fluorocytosine are ineffective against Aspergillus.
Understanding Aspergillus antifungal resistance is critical for developing effective treatment strategies.