Related Experiment Video

Updated: Feb 19, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

1.2K

Organization of Patient Management and Fungal Epidemiology in Cystic Fibrosis

Carsten Schwarz1, Jean-Philippe Bouchara2,3, Walter Buzina4

  • 1Department of Pediatric Pneumology and Immunology, Cystic Fibrosis Center Berlin/Charité-Universitätsmedizin Berlin, Berlin, Germany.

Mycopathologia
|November 4, 2017
PubMed

Insights

Improved cystic fibrosis (CF) patient outcomes stem from enhanced management and infection control. This study reviews effective CF patient care strategies and European fungal epidemiology, analyzing data from 3,235 patients.

Area of Science:

  • Medical Mycology
  • Pulmonology
  • Infectious Diseases

Background:

  • Cystic Fibrosis (CF) management has significantly improved over the past 30 years.
  • Enhanced infection control and patient care strategies are key to better quality of life for CF patients.
  • Fungal infections represent a growing concern in the CF population.

Purpose of the Study:

  • To summarize essential components of effective cystic fibrosis patient management.
  • To provide an overview of current knowledge on fungal epidemiology in European CF patients.
  • To highlight the importance of understanding fungal pathogens in CF care.

Main Methods:

  • Retrospective analysis of clinical data.
  • Inclusion of 66,616 samples from 3,235 cystic fibrosis patients.
  • Data collected from 9 cystic fibrosis centers across various European countries.

Main Results:

  • The study presents a comprehensive dataset on fungal prevalence in European CF patients.
  • Analysis of epidemiological data provides insights into common fungal species and their distribution.
  • Findings underscore the need for targeted antifungal strategies in CF care.

Conclusions:

  • Effective management of cystic fibrosis requires a multifaceted approach, including robust infection control.
  • Understanding the fungal epidemiology in CF patients is crucial for optimizing treatment and improving patient outcomes.
  • Continued research and surveillance are necessary to combat fungal infections in this vulnerable population.
Keywords:
Cystic fibrosisEpidemiologyFungal infection

More Related Videos

Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression08:58

Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression

Published on: April 18, 2025

1.1K
Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

1.9K

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
554
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
917
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
1.5K
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
583
Overview of Fungi01:29

Overview of Fungi

Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
2.0K
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
1.7K