Related Experiment Video

Updated: May 15, 2026

An Ex Vivo Laser-induced Spinal Cord Injury Model to Assess Mechanisms of Axonal Degeneration in Real-time
11:18

An Ex Vivo Laser-induced Spinal Cord Injury Model to Assess Mechanisms of Axonal Degeneration in Real-time

Published on: November 25, 2014

BACE1 influences debris clearance and axonal regeneration in injured peripheral nerve

Mohamed H Farah1

  • 1Department of Neurology, Johns Hopkins School of Medicine, 855 N. Wolfe St., Baltimore, MD 21205, USA. mfarah2@jhmi.edu

Journal of the Peripheral Nervous System : JPNS
|January 3, 2013
PubMed

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...