Related Experiment Video
Updated: May 15, 2026
Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
Nonablative fractional laser resurfacing for the treatment of hypertrophic scars: a randomized controlled trial
Evelien Verhaeghe1, Katia Ongenae, Jessica Bostoen
1Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
Background:
Nonablative fractional laser (NAFL) therapy is a noninvasive procedure that has been suggested as a treatment option for hypertrophic scars.
Objectives:
To evaluate the efficacy and safety of 1540-nm NAFL therapy in the treatment of hypertrophic scars.
Materials And Methods:
An intraindividual randomized controlled trial (RCT) with split lesion design and single-blinded outcome evaluations. Patients received four NAFL treatments at monthly intervals. Primary endpoint was a blinded on-site visual and palpable Physician Global Assessment (PhGA). Adverse event registration and pain evaluation were used to evaluate safety. Patient global assessment (PGA) was a secondary endpoint to additionally evaluate efficacy.
Results:
The PhGA did not find a statistically significant difference between the treated and untreated control side of 18 patients, although there was significant difference on the PGA 1 (p = .006) and 3 (p = .02) months after last treatment (Wilcoxon signed rank test). Patients experienced moderate pain during treatment and mild adverse events.
Conclusion:
In this trial, blinded PhGA could not confirm the clinical efficacy of 1540-nm nonablative fractional laser in the treatment of hypertrophic scars, but the treatment is safe, and patients judged that the treated part had a better global appearance.
