Related Experiment Video
Updated: May 15, 2026
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Transvaginal Mesh Insertion in the Ovine Model
Published on: July 27, 2017
Does pelvic mesh treated with phosphorylcholine improve outcomes? An early experience
Amit Chakrabarty1, Kumaresan Ganabathi, J Steven Alexander
1Urologic Clinics of North Alabama, Huntsville, AL 35801, USA. amitcmd@yahoo.com
Summary
This pilot study shows phosphorylcholine (PC) treated mesh for pelvic organ prolapse treatment is safe and effective. PC mesh reduced inflammatory responses and complications, with 100% anatomical success in early follow-up.
Area of Science:
- Biomaterials Science
- Urogynecology
- Medical Device Innovation
Background:
- Implantable devices benefit from phosphorylcholine (PC) surface modification, reducing host inflammatory responses.
- PC has been successfully used in cardiac and ophthalmic applications.
- Pelvic organ prolapse (POP) treatment often involves surgical mesh, with potential for complications.
Purpose of the Study:
- To evaluate the safety and efficacy of PC-treated polypropylene mesh grafts for pelvic organ prolapse treatment.
- To assess the impact of PC surface modification on mesh-related complications in POP surgery.
Main Methods:
- A pilot study involving 40 subjects implanted with Perigee IntePro Lite+PC mesh across five U.S. sites.
- Data collected included demographics, prolapse severity, anatomical outcomes (POPQ/Baden Walker staging), symptomatic improvement, and complications.
- Follow-up assessments were conducted at 5-7 months post-implantation.
Main Results:
- 80% of subjects completed the 5-7 month follow-up.
- No cases of mesh exposure, extrusion, or granuloma formation were reported.
- 100% anatomical success rate (≤Stage I POPQ or Baden Walker) was achieved at 5-7 months.
Conclusions:
- This is the first study on PC-treated pelvic mesh, showing no adverse events linked to the surface modification.
- While results are not statistically significant due to small numbers, PC surface modification shows promise for reducing mesh complications in POP treatment.
- Further research is warranted to confirm the long-term efficacy and safety of PC-treated pelvic mesh.
