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Updated: May 15, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels
Manuel Schmidt1, Han Sun, Andrei Leonov
1Max Planck Institute for Biophysical Chemistry, NMR II, 37077 Göttingen, Germany.
Abstract:
A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl.
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