Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calorie Needs of Older People With Restrictive Eating Disorders Undergoing Refeeding.

European eating disorders review : the journal of the Eating Disorders Association·2026
Same author

Compulsive exercise in higher levels of eating disorder care: Trajectory of change over time among adolescents with anorexia nervosa.

Eating behaviors·2026
Same author

Family Functioning Among Adolescent Males With Restrictive Eating Disorders: A Comparison to Matched Adolescent Females.

European eating disorders review : the journal of the Eating Disorders Association·2026
Same author

Eating disorder severity and treatment outcome across race/ethnicity, sexual orientation, and socioeconomic status: Intersectional inequities in a clinical sample.

Social science & medicine (1982)·2026
Same author

Family Functioning Among Adolescents With Avoidant/Restrictive Food Intake Disorder.

European eating disorders review : the journal of the Eating Disorders Association·2026
Same author

Causes of death in patients with a history of severe Anorexia Nervosa.

Journal of psychiatric research·2026

Related Experiment Video

Updated: May 15, 2026

Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
18:47

Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction

Published on: March 7, 2013

Elevation of liver function tests in severe anorexia nervosa.

R Hill Harris1, Gila Sasson, Philip S Mehler

  • 1Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA.

The International Journal of Eating Disorders
|January 3, 2013
PubMed
Summary

Liver function test abnormalities can occur when refeeding patients with severe anorexia nervosa (AN). This may be due to glucose deposition or liver cell death from prolonged starvation.

Related Experiment Videos

Last Updated: May 15, 2026

Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
18:47

Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction

Published on: March 7, 2013

Area of Science:

  • Hepatology
  • Endocrinology
  • Psychiatry

Background:

  • Anorexia nervosa (AN) is a complex eating disorder with significant medical complications.
  • Liver function test (LFT) abnormalities are observed in some AN patients, but their etiology requires clarification.

Observation:

  • Refeeding patients with severe AN can precipitate abnormal elevations in LFTs.
  • Two cases illustrate severe LFT abnormalities during medical stabilization for AN.

Findings:

  • Elevated LFTs during refeeding in AN are attributed to excessive hepatic glucose deposition.
  • Alternatively, LFT abnormalities may indicate hepatocellular death resulting from prolonged starvation preceding adequate nutritional rehabilitation.

Implications:

  • Understanding the mechanisms behind LFT changes is crucial for managing AN patients.
  • This knowledge aids in optimizing refeeding protocols to prevent or mitigate liver injury in AN.