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Related Experiment Video

Updated: May 15, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

Mouse models of frontotemporal dementia.

Erik D Roberson¹

¹Departments of Neurology and Neurobiology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama, Birmingham, AL 35294, USA. eroberson@uab.edu

Annals of Neurology

|January 3, 2013

Summary

Frontotemporal dementia (FTD) research advances with new genetic discoveries like MAPT/tau and GRN/progranulin. Mouse models are crucial for understanding FTD pathogenesis and developing future therapies.

Area of Science:

Neuroscience
Genetics
Neurology

Background:

Frontotemporal dementia (FTD) discovery pace has accelerated.
MAPT/tau, GRN/progranulin, and C9ORF72 are common FTD genes.
TDP-43, FUS, and tau are common neuropathological substrates.

Purpose of the Study:

Review recent progress with mouse models for FTD.
Discuss future prospects for FTD models.
Highlight opportunities in FTD research.

Main Methods:

Review of mouse models based on tau, TDP-43, progranulin, VCP, and CHMP2B.
Analysis of conserved salience network in FTD.
Utilizing FTD-related behavioral paradigms.

Main Results:

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Mouse models are vital tools for FTD pathogenesis research.
Identified common and less common genetic causes of FTD.
TDP-43 and FUS are key neuropathological substrates.

Conclusions:

Continued development of FTD mouse models is essential.
Understanding genetic and neuropathological substrates aids FTD research.
Exploring conserved networks and behavioral paradigms offers future research avenues.