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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Related Experiment Video

Updated: May 15, 2026

Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Nodal and leukemic small B-cell neoplasms.

James R Cook1

  • 1Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. Cookj2@ccf.org

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|January 3, 2013
PubMed
Summary

This review covers diagnostic criteria for small B-cell neoplasms and precursor conditions. It discusses new immunohistochemical stains and molecular studies for accurate classification in surgical pathology.

Related Experiment Videos

Last Updated: May 15, 2026

Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Small B-cell neoplasms are common lymphoproliferative disorders encountered in surgical pathology.
  • Accurate classification is crucial for patient management and treatment strategies.

Purpose of the Study:

  • To review current diagnostic criteria for small B-cell neoplasms.
  • To differentiate these neoplasms from precursor conditions lacking overt lymphoma features.
  • To discuss novel diagnostic tools, including immunohistochemistry and molecular studies.

Main Methods:

  • Review of current literature and diagnostic guidelines.
  • Analysis of diagnostic criteria for small B-cell neoplasms.
  • Evaluation of newly available immunohistochemical stains and molecular techniques.

Main Results:

  • Established criteria for classifying small B-cell neoplasms.
  • Identified key features to distinguish lymphomas from precursor conditions.
  • Highlighted the utility of advanced diagnostic modalities.

Conclusions:

  • Accurate diagnosis of small B-cell neoplasms relies on established criteria and differentiation from precursor lesions.
  • Immunohistochemistry and molecular studies significantly enhance diagnostic precision.
  • These advancements are vital for effective patient care in surgical pathology.