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Published on: May 10, 2017
Extranodal and splenic small B-cell lymphoma.
1Department of Histopathology, Royal Marsden Hospital, London, UK. andrew.wotherspoon@rmh.nhs.uk
Summary
This review covers small B-cell lymphomas originating in the spleen and extranodal sites, highlighting their unique behaviors. It provides guidance on differentiating these lymphomas from reactive conditions and from each other.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Non-Hodgkin lymphomas can disseminate to the spleen and extranodal sites.
- A distinct subset of small B-cell lymphomas specifically originates in these locations.
- These lymphomas may exhibit unique behaviors and prognoses compared to nodal forms.
Purpose of the Study:
- To review the characteristics of small B-cell lymphomas arising in the spleen and extranodal sites.
- To provide diagnostic clues for distinguishing these lymphomas from reactive infiltrates.
- To outline methods for differentiating between splenic and extranodal small B-cell lymphomas.
Main Methods:
- Literature review of small B-cell lymphomas in extranodal sites and the spleen.
- Analysis of diagnostic features differentiating lymphoma from reactive processes.
- Comparison of clinicopathologic features of nodal versus extranodal/splenic lymphomas.
Main Results:
- Specific entities like extranodal marginal zone lymphoma arise in extranodal locations.
- Splenic lymphomas can involve either the red or white pulp.
- Distinguishing features exist to differentiate these lymphomas from reactive conditions and from each other.
Conclusions:
- Recognition of splenic and extranodal small B-cell lymphomas is crucial due to potentially distinct behaviors.
- Accurate differentiation from reactive infiltrates and between lymphoma subtypes is essential for appropriate patient management.
- This review offers guidance for pathologists and clinicians encountering these specific lymphoma entities.
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