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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: May 15, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Colon carcinogenesis in inflammatory bowel disease.

S H Itzkowitz1, B Greenwald, S J Meltzer

  • 1Department of Medicine, Mount Sinai School of Medicine, New York City, New York; and Departments of *Medicine, and †Pathology, Oncology, and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, U.S.A.

Inflammatory Bowel Diseases
|January 4, 2013
PubMed
Summary

Colon cancers in inflammatory bowel disease (IBD) show distinct molecular changes compared to sporadic cancers. Understanding these differences in colitis-associated neoplasms is key for improved patient management.

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Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

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Published on: March 10, 2015

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Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
12:37

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

Area of Science:

  • Gastroenterology
  • Oncology
  • Molecular Biology

Background:

  • Colitis-associated neoplasms share some features with sporadic colon cancers, but molecular alterations are less understood.
  • Phenotypic changes like increased sialomucin and decreased sialic acid O-acetylation correlate with malignant progression in IBD.

Purpose of the Study:

  • To investigate the molecular and genetic alterations in colitis-associated colon neoplasms.
  • To compare these alterations with those found in sporadic colon carcinogenesis.

Main Methods:

  • Analysis of phenotypic alterations including mucin expression and sialic acid O-acetylation.
  • Assessment of molecular genetic changes such as genomic instability, aneuploidy, protooncogene activation, and tumor suppressor gene mutations.

Main Results:

  • Increased sialomucin and decreased sialic acid O-acetylation suggest small intestinal metaplasia during carcinogenesis.
  • Genomic instability and aneuploidy are associated with malignant progression.
  • Activation of k-ras, c-src and alterations in p53, APC genes occur, with potentially different timing than in sporadic cancers. Microsatellite instability is present, but mismatch repair gene mutations are not yet described.

Conclusions:

  • Colitis-associated carcinogenesis involves distinct molecular and genetic pathways.
  • Further research is needed to fully understand the pathobiology and guide clinical management of IBD-associated colon cancer.