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Autoxidation of ascorbic acid catalyzed by a semisynthetic enzyme
1Laboratory of Bioorganic Chemistry and Biochemistry, Rockefeller University, New York, New York 10021.
Biopolymers
|January 1, 1990
Abstract:
The semisynthetic enzyme 6 was prepared by alkylation of the cysteine-25 sulfhydryl group of papain with the bipyridine 5 and was shown to stoichiometrically bind copper ion; 7 catalyzed the autoxidation of ascorbic acid derivatives with saturation kinetics approximately 20-fold faster than a model system using 3-Cu(II).