Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Cross-reactivity00:42

Cross-reactivity

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural Mucosal Response to Dupilumab in Chronic Rhinosinusitis With Nasal Polyps: A Pilot Study.

Clinical and translational allergy·2026
Same author

Clinical Evaluation of Allergen Immunotherapy for Allergic Rhinitis.

Vaccines·2026
Same author

The definition of response and inadequate response to topical corticosteroid treatment in atopic dermatitis and related skin inflammatory diseases: A GA<sup>2</sup>LEN ADCARE statement paper.

The World Allergy Organization journal·2026
Same author

Three years treatment with HDM allergen immunotherapy, omalizumab, or combination therapy in allergic asthma: clinical outcomes and biomarkers.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Geographical variability in severe asthma: comparison of patients' characteristics between national, regional, and international cohorts in ISAR.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Allergic rhinitis activity and efficacy of 300 IR house dust mite sublingual immunotherapy tablet in pediatrics.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026

Related Experiment Video

Updated: May 15, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Is sublingual immunotherapy the final answer? Implications for the allergist.

Giorgio Walter Canonica1, Giovanni Passalacqua

  • 1From the Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy. This work has been partially supported by the Associazione Ricerca Malattie Immunologiche e Allergiche.

The World Allergy Organization Journal
|January 4, 2013
PubMed
Summary

Sublingual immunotherapy (SLIT), an alternative to injections, is effective and safe, even for children. Allergists can use this convenient option after a specialist diagnosis.

More Related Videos

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Area of Science:

  • Allergy and immunology
  • Immunotherapy research

Background:

  • Sublingual immunotherapy (SLIT) is supported by over 40 clinical trials and meta-analyses.
  • SLIT presents a favorable safety profile, including in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy and safety of sublingual immunotherapy (SLIT).
  • To position SLIT as a viable therapeutic option for allergists.

Main Methods:

  • Review of over 40 clinical trials and meta-analyses on SLIT efficacy.
  • Assessment of safety data, particularly in younger children.

Main Results:

  • SLIT is a proven, effective alternative to traditional injection immunotherapy.
  • SLIT demonstrates a highly favorable safety profile and patient convenience.
  • Further research is needed on optimal dosing, patient selection, and mechanisms of action.

Conclusions:

  • Sublingual immunotherapy is an established and valuable therapeutic option for allergists.
  • The tolerability, safety, and convenience are key advantages of SLIT.
  • Specialist prescription and accurate diagnosis are mandatory for SLIT, similar to injection immunotherapy.