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Updated: May 15, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
(±)-(rel-3R,3'R)-1,1'-Dimethyl-3,3'-bipyrrolidine-2,2'-dithione
Lee G Madeley1, Andreas Lemmerer, Joseph P Michael
1Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO Wits, 2050 Johannesburg, South Africa.
Abstract:
The asymmetric unit of the racemic title compound, C(10)H(16)N(2)S(2), a C(2)-symmetric bis-(thiol-actam), contains one half-mol-ecule, the complete mol-ecule being generated by a twofold axis symmetry operation. The five-membered ring is nearly planar, with a maximum deviation of 0.025 (1) Å. In the crystal, the mol-ecules are linked via weak C-H⋯S inter-actions, forming infinite chains along the b-axis direction.
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