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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Videos

Osteointegration in oncologic patients: a case report.

Fabrizio Carini1, Concetta Bucalo, Vito Saggese

  • 1Research Professor, University of Milan-Bicocca, Monza (MB), Italy.

Annali Di Stomatologia
|January 4, 2013
PubMed
Summary

Dental implants can successfully restore quality of life for oral cancer patients, even after cancer recurrence. This case report highlights the long-term success of osseointegrated implants in patients with mandibular cancer.

Keywords:
neoplastic relapsesoral canceroral surgeyosseointegrationprosthetic rehabilitation

Related Experiment Videos

Area of Science:

  • Oral oncology
  • Implant dentistry
  • Reconstructive surgery

Background:

  • Oral cancer resection often necessitates complex rehabilitation.
  • Implant-prosthetic rehabilitation can significantly improve quality of life for affected patients.

Purpose of the Study:

  • To illustrate the efficacy of implant-prosthetic rehabilitation in enhancing the quality of life for patients undergoing oral cancer resection.
  • To present a case study on the long-term outcomes of dental implants in a patient with mandibular cancer.

Main Methods:

  • A patient with verrucous squamous cell carcinoma of the mandible underwent surgical resection and subsequent prosthetic rehabilitation with three interforaminal dental implants and a Toronto bridge.
  • Cancer recurrence led to the removal of a jaw segment and one implant; histological examination assessed bone-implant contact.

Main Results:

  • Osseointegration of the dental implants was maintained despite the cancer recurrence in the same anatomical area.
  • Histological examination revealed healthy bone-to-implant contact, even in proximity to the neoplastic tissue.

Conclusions:

  • Endosseous implants are a viable and effective option for prosthetic rehabilitation in cancer patients.
  • Further long-term studies and numerical analyses are needed to validate these findings in larger patient cohorts.