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Updated: May 15, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets
David Paniagua-Vega1, Carlos M Cerda-García-Rojas, Teresa Ponce-Noyola
1Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, 07360 Mexico D. F., Mexico.
Abstract:
Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known alkaloids, tetrahydroalstonine (1), aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.
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