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Updated: May 15, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Verrucous lymphangioma circumscriptum.

Vitaly Terushkin¹, Shoshana Marmon, Max Fischer

¹The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.

Dermatology Online Journal

|January 5, 2013

Summary

This summary is machine-generated.

A rare verrucous lymphangioma circumscriptum, a common lymphatic malformation, can be challenging to diagnose. Surgical excision is definitive, but other therapies offer potential improvement.

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Last Updated: May 15, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Dermatology
Vascular Malformations
Medical Histopathology

Background:

Lymphangioma circumscriptum is the most common congenital lymphatic malformation.
Typically presents as grouped vesicles, but a verrucous variant poses diagnostic challenges.
This case highlights a 19-year-old female with a seven-year history of verrucous lesions.

Observation:

The patient presented with pruritic, grouped, verrucous papules and plaques on the left arm.
Lesions showed slight flattening with topical glucocorticoid treatment.
Histopathology confirmed lymphangioma circumscriptum.

Findings:

The verrucous presentation is a rare subtype of lymphangioma circumscriptum.
Histopathological features were diagnostic despite the atypical morphology.
Topical glucocorticoids provided minimal symptomatic relief.

Implications:

Definitive treatment involves surgical excision.
Alternative therapies like sclerotherapy, radiotherapy, and laser therapy have shown efficacy.
Propranolol is emerging as a potential future medical therapy for lymphangioma.