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Sulphonamides: Deserving class as MMP inhibitors?
Pranjali Jain1, Chinnadurai Saravanan, Sushil Kumar Singh
1Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (BHU), Varanasi 221005, India.
European Journal of Medicinal Chemistry
|January 5, 2013
Summary
Sulphonamides are a crucial drug class with emerging matrix metalloproteinase (MMP) inhibitory activity. This review explores their evolution, mechanism, and therapeutic potential in diseases like cancer and COPD.
Area of Science:
- Medicinal Chemistry
- Pharmacology
Background:
- Sulphonamides represent a vital class of drugs in medicinal chemistry.
- Recent research highlights their potential as inhibitors of matrix metalloproteinases (MMPs).
- MMPs are critical enzymes involved in cellular processes.
Purpose of the Study:
- To review the development of sulphonamides as matrix metalloproteinase inhibitors (MMPIs).
- To elucidate the mechanism of action of sulphonamides on MMPs.
- To explore the structure-activity relationships and therapeutic applications of MMPIs.
Main Methods:
- Literature review of sulphonamide-based MMPIs.
- Analysis of the evolution from first to third-generation MMPIs.
- Examination of structure-activity relationships and therapeutic uses.
Main Results:
- Sulphonamides have progressed through multiple generations as MMPIs.
- Their mode of action on MMPs has been elucidated.
- Significant therapeutic potential is identified for various conditions.
Conclusions:
- Sulphonamides represent a promising class of matrix metalloproteinase inhibitors.
- Their established medicinal chemistry profile supports further development for therapeutic applications.
- Further research into sulphonamide MMPIs is warranted for conditions including COPD, ulcers, asthma, arthritis, and cancer.
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