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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Spermatogenesis01:22

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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Related Experiment Video

Updated: May 15, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

Intercellular adhesion molecules (ICAMs) and spermatogenesis.

Xiang Xiao1, Dolores D Mruk, C Yan Cheng

  • 1The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.

Human Reproduction Update
|January 5, 2013
PubMed
Summary
This summary is machine-generated.

Intercellular adhesion molecules (ICAMs) regulate key events in spermatogenesis, including germ cell movement and blood-testis barrier restructuring. This study identifies ICAM-1, ICAM-2, and soluble ICAM-1 as crucial for these processes.

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Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging
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Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging

Published on: May 24, 2013

Related Experiment Videos

Last Updated: May 15, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
05:44

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging
19:26

Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging

Published on: May 24, 2013

Area of Science:

  • Reproductive biology
  • Cell biology
  • Molecular endocrinology

Background:

  • Spermatogenesis involves complex cellular rearrangements within the seminiferous epithelium, requiring coordinated events at Sertoli-Sertoli and Sertoli-germ cell interfaces.
  • The blood-testis barrier (BTB) and apical ectoplasmic specialization (ES) form a functional axis that regulates germ cell movement and differentiation during the epithelial cycle.
  • The specific molecular regulators coordinating these critical events within the apical ES-BTB-basement membrane axis remain largely unknown.

Purpose of the Study:

  • To identify the regulatory molecules involved in coordinating cellular events within the apical ectoplasmic specialization (ES)-blood-testis barrier (BTB)-basement membrane axis during spermatogenesis.
  • To investigate the role of intercellular adhesion molecules (ICAMs) in regulating junction restructuring and cell adhesion during the seminiferous epithelial cycle.

Main Methods:

  • A comprehensive literature search was conducted using PubMed and Google Scholar.
  • Published findings on intercellular adhesion molecules (ICAMs) and their regulation of the apical ES-BTB-basement membrane axis were identified and analyzed.
  • Information from other epithelia/endothelia regarding ICAM function in cell movement was integrated with testicular studies.

Main Results:

  • Members of the ICAM family, specifically ICAM-1, ICAM-2, and soluble ICAM-1 (sICAM-1), are identified as likely key regulators.
  • ICAM-1 and sICAM-1 exhibit antagonistic effects on the Sertoli cell tight junction-permeability barrier, influencing BTB restructuring.
  • ICAM-2 is localized to the apical ES and plays a role in regulating spermatid adhesion throughout the epithelial cycle.

Conclusions:

  • Intercellular adhesion molecules (ICAMs) are essential regulatory components of spermatogenesis.
  • A hypothetical model is proposed, illustrating how ICAMs orchestrate junction restructuring events during sperm development.
  • This model provides a foundation for future functional experiments to elucidate ICAM mechanisms in the testis.