[Preliminary study of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease
Yong Xu1, Jun-song Liu, Guang Zhi
1Department of Cardiology, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, China. yongxu301@163.com
Insights
Real-time three-dimensional dobutamine stress echocardiography effectively assesses coronary artery disease (CAD) with high accuracy and safety. This rapid technique shows promise for broader clinical use in diagnosing CAD.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Coronary artery disease (CAD) diagnosis relies on accurate imaging modalities.
- Echocardiography offers a non-invasive approach to cardiac assessment.
Purpose of the Study:
- To evaluate the efficacy and safety of real-time three-dimensional dobutamine stress echocardiography (RT3D-DSE) for CAD assessment.
- To compare the diagnostic performance of RT3D-DSE with coronary angiography (CAG).
Main Methods:
- 14 patients with suspected CAD underwent RT3D-DSE with escalating dobutamine doses.
- Wall motion score index (WMSI) and regional ejection fraction (rEF) were assessed.
- RT3D-DSE parameters were compared against CAG results.
Main Results:
- RT3D-DSE demonstrated no significant difference compared to CAG (P > 0.05).
- Satisfactory agreement was observed between RT3D-DSE and CAG (κ values 0.704 and 0.759).
- Diagnostic parameters included high sensitivity (up to 89%) and specificity (up to 92%).
Conclusions:
- RT3D-DSE is an effective, rapid, and safe method for assessing CAD.
- The technique shows good diagnostic accuracy and agreement with CAG.
- RT3D-DSE warrants wider clinical application for CAD evaluation.
Objective:
To evaluate the efficacy and safety of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease assessment.
Methods:
A total of 14 patients suspected of coronary artery disease (CAD) underwent real-time three-dimensional dobutamine stress echocardiography. The initial infusion rate of dobutamine was 5 µg×kg⁻¹ ×min⁻¹, followed by 10 µg×kg⁻¹×min⁻¹ and peak infusion 20 µg×kg⁻¹×min⁻¹ in 3 min stages. At baseline state, stress stages and after the study, the real-time three-dimensional (RT3D) images were captured and assessed by wall motion score index (WMSI) and regional ejection fraction (rEF). And the parameters of these two modalities versus coronary angiography (CAG) were compared and analyzed. Adverse reactions were also observed.
Results:
All patients completed the stress study uneventfully. As compared with CAG, these two modalities showed no significant difference (P > 0.05) and satisfactory agreement (κ values of 0.704 and 0.759 respectively). The diagnostic parameters of these modalities were: sensitivity (78% vs 89%), specificity (92% vs 88%), positive predictive value (PPV) (88% vs 84%), negative predictive value (NPV) (85% vs 91%) and overall accuracy (86% vs 88%).
Conclusion:
Real-time three-dimensional dobutamine stress echocardiography is an effective, rapid and safe technique of assessing coronary artery disease. It is worthy of wider clinical applications.
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