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Updated: May 15, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Clinical manifestations and natural history of diabetic kidney disease
1University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, Heidelberg 69120, Germany. bueroritz@gmx.de
Abstract:
Renal failure in type 2 diabetes has been termed "a medical catastrophe of worldwide dimension". In 2001, we found in our unit that 49% of incident patients requiring maintenance hemodialysis had diabetes (i.e. 98/million population/year), 6% of whom had type 1 and most (94%) had type 2 diabetes, i.e. more than the than reported frequency in Germany (approximately 35% of incident patients). The frequency is underestimated because hyperglycemia is often lost in the preterminal phase when diabetic patients lose weight and fasting hyperglycemia.
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