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Bi-phasic effect of equol on adipocyte differentiation of MC3T3-L1 cells
Yoriko Nishide1, Yuko Tousen, Masaki Inada
1Department of Food Function and Labeling, National Institute of Health and Nutrition, Tokyo, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 8, 2013
Abstract:
We investigated the effects of equol on adipogenesis by measuring lipid accumulation and analyzing the change in adipocyte-related gene expression in MC3T3-L1 cells. Treatment with 10 µM equol tended to increase adipocyte-related gene expression, whereas 100 µM equol reduced lipid accumulation and suppressed the expression of these genes and proteins. Our results suggest that equol regulated adipogenesis in a bi-phasic fashion.
