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Updated: May 15, 2026

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Viral subversion of host functions for picornavirus translation and RNA replication
Amanda J Chase1, Bert L Semler
1Department of Microbiology & Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA.
Abstract:
Picornavirus infections lead to symptoms that can have serious health and economic implications. The viruses in this family (Picornaviridae) have a small genomic RNA and must rely on host proteins for efficient viral gene expression and RNA replication. To ensure their effectiveness as pathogens, picornaviruses have evolved to utilize and/or alter host proteins for the benefit of the virus life cycle. This review discusses the host proteins that are subverted during infection to aid in virus replication. It will also describe proteins and functions that are altered during infection for the benefit of the virus.
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