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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
A two-photon fluorescent probe for amyloid-β plaques in living mice
Cheol Ho Heo1, Kyung Ho Kim, Hyung Joong Kim
1Division of Energy Systems Research, Ajou University, Suwon, 443-749, Korea.
Chemical Communications (Cambridge, England)
|January 9, 2013
Abstract:
We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.
