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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jun 24, 2026

Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice

Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice

Published on: June 2, 2023

Monitoring Alzheimer's disease-related fluid microenvironment changes using magnetic resonance-based electrical

Bup Kyung Choi¹, Ji Ae Park¹, Tae Hoon Kim²

¹Division of Applied RI, Korea Institute of Radiological and Medical Science, Seoul, Republic of Korea.

Journal of Alzheimer'S Disease : JAD

|June 23, 2026

Summary

Alzheimer's disease (AD) involves brain fluid changes. Conductivity imaging revealed elevated cerebrospinal fluid (CSF) conductivity in AD mice, highlighting its potential as a diagnostic marker.

Keywords:

5XFAD Alzheimer's disease cerebrospinal fluid electrical conductivity hippocampus magnetic resonance imaging

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Area of Science:

Neuroimaging
Biophysics
Alzheimer's Disease Research

Background:

Cerebrospinal fluid (CSF) dysfunction is linked to Alzheimer's disease (AD) progression and impaired waste clearance.
Magnetic resonance (MR)-based conductivity imaging offers a novel method to assess ion concentration and mobility within brain tissues.

Purpose of the Study:

To investigate the utility of MR conductivity imaging in detecting pathological changes in the brain of a mouse model of Alzheimer's disease.
To evaluate regional conductivity differences in the cerebrospinal fluid and brain parenchyma of 5xFAD mice compared to wild-type controls.

Main Methods:

High-field (9.4T) MR conductivity imaging was applied to 5xFAD mice and age-matched wild-type controls.
Regional conductivity was measured in the ventricular CSF, caudate putamen, cerebral cortex, thalamus, and hippocampus.
Analysis focused on identifying differences in conductivity associated with AD pathology.

Main Results:

AD mice exhibited ventricular enlargement and significantly elevated conductivity in the cerebrospinal fluid (CSF).
Increased hippocampal conductivity was observed in AD mice, correlating with known AD pathology.
No significant conductivity changes were detected in the caudate putamen, cerebral cortex, or thalamus.

Conclusions:

MR-based conductivity imaging can detect microenvironmental fluid changes in the brain associated with Alzheimer's disease.
Elevated CSF conductivity in AD mice suggests potential as a biomarker for metabolic dysfunction and disease progression.
Further research is warranted to explore the clinical applicability of conductivity imaging in human AD diagnosis.