Ultrasonographic Assessment of Hepatic Capsular Thickness in Fitz-Hugh-Curtis Syndrome: Correlation with Computed...

To investigate whether hepatic capsular thickness (HCT) measured on ultrasonography (US) is associated with HCT measured on arterial-phase computed tomography (CT), and to evaluate the potential discriminative performance of US-measured HCT in women with Fitz-Hugh-Curtis syndrome (FHCS).

In this retrospective dual-center case-control study, 17 women with clinically diagnosed FHCS who underwent both arterial-phase CT and abdominal US within a 3-day interval were included. Thirty-five healthy women served as controls. HCT was measured on CT and US by two abdominal radiologists blinded to clinical information. HCT values were compared between groups, the association between CT and US measurements was assessed, interobserver agreement was evaluated using the intraclass correlation coefficient (ICC), and receiver operating characteristic analysis was performed to explore candidate cutoff values for discriminating FHCS from controls.

Median HCT on CT was significantly greater in the FHCS group than in the control group [1.80 mm (IQR, 1.60-2.00) vs. 0.60 mm (IQR, 0.40-0.70); U = 595.0, p < 0.001]. Median HCT on US was also significantly greater in the FHCS group than in the control group [1.50 mm (IQR, 1.30-2.00) vs. 0.70 mm (IQR, 0.60-0.80); U = 589.0, p < 0.001]. CT- and US-based HCT measurements showed a significant positive correlation (rho = 0.66, p < 0.001). Interobserver agreement for HCT measurement was good in the overall cohort (ICC, 0.804; 95% confidence interval [CI], 0.66-0.89). In exploratory receiver operating characteristic (ROC) analysis, the candidate cutoff values were 1.1 mm for CT and 0.85 mm for US. These ROC-derived metrics should be interpreted as exploratory estimates from an idealized case-control setting rather than as real-world diagnostic performance.

US-measured HCT was significantly increased in women with clinically diagnosed FHCS and showed a significant positive correlation of moderate strength with CT-measured HCT. These findings suggest that US-based HCT assessment may provide supportive imaging information in patients with suspected FHCS. Further validation in larger cohorts, particularly in clinically relevant control populations, is warranted.