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Bone tuberculosis in Roman Period Pannonia (western Hungary)
Tamás Hajdu1, Erzsébet Fóthi, Ivett Kovári
1Department of Biological Anthropology, Institute of Biology, Faculty of Science, Eötvös Loránd University, Budapest, Hungary. hajdut@elte.hu
Memorias Do Instituto Oswaldo Cruz
|January 9, 2013
Summary
This study analyzed a Roman-era skeleton from Hungary with tuberculous spondylitis. Biomolecular analyses confirmed the diagnosis of this ancient bone disease.
Area of Science:
- Paleopathology
- Bioarchaeology
- Ancient Infectious Diseases
Background:
- Tuberculous spondylitis is a serious spinal infection.
- Analyzing ancient remains offers insights into historical disease prevalence.
- Roman Period Hungary provides a unique context for studying past health conditions.
Observation:
- A skeleton of an adult female (25-30 years) from Roman Period Hungary (3rd-6th centuries) exhibited signs of tuberculous spondylitis.
- The skeleton was excavated near Győr, western Hungary.
- Gross observation revealed characteristic skeletal lesions.
Findings:
- Mycolic acid analysis and proteomic analysis using MALDI-TOF/TOF tandem mass spectrometry were performed.
- Biomolecular analyses provided strong support for the morphological diagnosis of tuberculous spondylitis.
- The combination of methods confirmed the presence of tuberculosis in the ancient spine.
Implications:
- This research validates the use of advanced biomolecular techniques in paleopathology.
- It contributes to understanding the history and spread of tuberculosis in ancient populations.
- The findings enhance our knowledge of skeletal diseases in Roman-era Hungary.
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