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Updated: May 15, 2026

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Published on: March 18, 2020

Common variable immunodeficiency and isosporiasis: first report case.

Gisele Barbosa E Silva¹, Karla Pereira Fernandes, Gesmar Rodrigues Silva Segundo

¹Hospital de Clínicas, Universidade Federal de Uberlândia, Uberlândia, MG.

Revista Da Sociedade Brasileira De Medicina Tropical

|January 9, 2013

Summary

A severe case of diarrhea in an HIV-negative patient revealed opportunistic infections, Giardia lamblia and Isospora belli. This led to a diagnosis of common variable immunodeficiency (CVID), highlighting the link between primary immunodeficiency and parasitic infections.

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Last Updated: May 15, 2026

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Published on: March 18, 2020

Area of Science:

Infectious Diseases
Immunology
Gastroenterology

Background:

Opportunistic infections can indicate underlying immunological disorders.
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia.

Observation:

A 62-year-old HIV-negative female presented with severe diarrhea.
Diagnostic investigations isolated Giardia lamblia and Isospora belli from the patient.

Findings:

The patient was diagnosed with common variable immunodeficiency (CVID).
This case represents the first reported instance of isosporiasis in a patient with CVID.

Implications:

Unusual infections warrant immunological assessment, especially in primary immunodeficiency.
Awareness of the link between CVID and opportunistic parasitic infections is crucial for diagnosis and management.