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Vesicoureteral reflux and urodynamic dysfunction.

Danica Batinic1, Danko Miloševic, Marija Topalovic-Grkovic

  • 1Nephrology Department, University Children's Hospital, Clinical Hospital Center, Zagreb, Croatia. danka.batinic@zg.t-com.hr

Urologia Internationalis
|January 9, 2013
PubMed
Summary
This summary is machine-generated.

Vesicoureteral reflux (VUR) in children is often linked to lower urinary tract dysfunction, leading to high bladder pressure. This study found that most children with VUR have abnormal urodynamics, particularly overactive bladder or dysfunctional voiding.

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Area of Science:

  • Pediatric Urology
  • Urodynamics
  • Lower Urinary Tract Dysfunction

Background:

  • Vesicoureteral reflux (VUR) is increasingly recognized as associated with lower urinary tract dysfunction (LUTD).
  • LUTD can cause high intravesical pressure, predisposing children to VUR.
  • This challenges the traditional view of VUR solely as a consequence of congenital anomalies.

Purpose of the Study:

  • To investigate the urodynamic findings in children diagnosed with VUR.
  • To determine the prevalence of lower urinary tract dysfunction in this pediatric population.

Main Methods:

  • Urodynamic assessment using pressure-flow-EMG studies.
  • Evaluated 132 children with VUR, analyzing 162 refluxing units.
  • Classified VUR grades and correlated findings with age and presence of uroinfections.

Main Results:

  • A significant majority (75%) of children with VUR exhibited abnormal urodynamic findings.
  • Overactive bladder (OAB) was the most common abnormality (44.7%), followed by dysfunctional voiding (DV) (18.9%).
  • Lower VUR grades (I and II) were associated with a higher incidence of pathological urodynamics, particularly OAB in younger children.

Conclusions:

  • Pediatric VUR frequently coexists with significant urodynamic disorders.
  • Urodynamic dysfunction likely plays a role in the pathogenesis of VUR, especially in milder forms.
  • Identifying and managing LUTD is crucial in children with VUR.