Related Experiment Video
Updated: May 15, 2026

Characterizing Bacterial Volatiles using Secondary Electrospray Ionization Mass Spectrometry (SESI-MS)
Published on: June 8, 2011
Carbonation and other super saturated gases as solution modifiers for improved sensitivity in solvent assisted
Vincent S Pagnotti1, Shubhashis Chakrabarty, Charles N McEwen
1University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA.
Abstract:
Solvent Assisted Ionization Inlet (SAII) produces ions in a heated inlet to a mass spectrometer from aqueous and aqueous/organic solutions with high sensitivity. However, the use of acid modifiers, which typically aids electrospray ionization, generally results in ion suppression in SAII. Here we demonstrate that the use of carbonation and other super-saturated gases as solution modifiers increases analyte ion abundance and reduces metal cation adduction in SAII. Carbonation is also found to enhance electrospray ionization. The mechanistic and practical utility of carbonation in mass spectrometry is addressed.
More Related Videos
Related Concept Videos
Electrospray Ionization (ESI) Mass Spectrometry
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Chemical Ionization (CI) Mass Spectrometry
Supercritical Fluid Chromatography
SFC utilizes a supercritical fluid mobile phase,...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
Ion-Exchange Chromatography
Atomic Emission Spectroscopy: Interference

