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Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Mass Analyzers: Common Types01:19

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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Mass Spectrometry: Complex Analysis01:21

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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Mass Analyzers: Overview01:13

Mass Analyzers: Overview

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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for

Sarah Trimpin1,2, Ellen Inutan3, Hope Coffinberger2,4

  • 1Wayne State University, Detroit, MI, USA.

European Journal of Mass Spectrometry (Chichester, England)
|November 24, 2023
PubMed
Summary

Sub-atmospheric pressure ionization mass spectrometry (MS) offers direct analysis of diverse samples. This new plate source concept enables rapid, sensitive, and robust MS applications beyond traditional laboratory settings.

Keywords:
Direct ionization mass spectrometryfastnovice userplate sourcerobustsafetysensitivesub-atmospheric pressure ionization mass spectrometry

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • Mass spectrometry (MS) has vast potential beyond academic labs.
  • Direct ionization methods are crucial for real-world sample analysis.

Purpose of the Study:

  • To present a novel plate source concept for sub-atmospheric pressure (AP) ionization MS.
  • To demonstrate the capabilities of this system for direct analysis of various samples.

Main Methods:

  • Utilized a plate source for direct sample introduction into the sub-AP region of an MS.
  • Employed sub-AP ionization MS for analyzing volatile and nonvolatile molecules.
  • Demonstrated adaptability for multiple ionization methods without venting.

Main Results:

  • Achieved direct, accurate, sensitive, and straightforward analysis of small to large molecules.
  • Successfully analyzed diverse and 'dirty' real-world samples.
  • Showcased the robustness and speed of the sub-AP ionization MS system.

Conclusions:

  • The plate source concept significantly expands the application scope of MS.
  • Sub-AP ionization MS offers a practical and safe alternative to ambient ionization.
  • This technology facilitates broader adoption of MS in various fields.