Synthetic mRNAs with superior translation and stability properties

Ewa Grudzien-Nogalska1, Joanna Kowalska, Wei Su

  • 1Department of Biochemistry and Molecular Biology, Lousisiana State University Health Sciences Center, Shreveport, LA, USA.

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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