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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Signals regulating L-selectin-dependent leucocyte adhesion and transmigration.
1Membrane/Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King's College London, London SE5 9NU, United Kingdom. aleksandar.ivetic@kcl.ac.uk
The International Journal of Biochemistry & Cell Biology
|January 10, 2013
Summary
L-selectin, a key molecule in leukocyte adhesion, plays a vital role in immune responses and inflammatory diseases. Understanding its downstream signaling pathways may reveal new therapeutic targets for various conditions.
Area of Science:
- Immunology
- Cell Biology
- Molecular Medicine
Background:
- L-selectin is a cell adhesion molecule on circulating leukocytes, crucial for immune cell trafficking.
- Its role in leukocyte recruitment to lymph nodes and inflammatory sites is established in knockout mouse models.
- L-selectin is a validated therapeutic target for inflammatory diseases.
Purpose of the Study:
- To review L-selectin-dependent intracellular signaling pathways.
- To explore signals arising from different stages of the leukocyte adhesion cascade.
- To investigate the role of L-selectin binding partners in cellular responses.
Main Methods:
- Literature review of studies on L-selectin function and signaling.
- Analysis of data from L-selectin knockout mice.
- Examination of clinical trial findings related to L-selectin.
Main Results:
- L-selectin regulates the recruitment of naive T-cells to lymph nodes.
- It is involved in the recruitment of monocytes and neutrophils to inflammatory sites.
- Distinct signaling events are associated with L-selectin's role in the adhesion cascade.
Conclusions:
- L-selectin-mediated signaling is critical in both health and inflammatory diseases.
- Further understanding of these signals can identify novel, specific therapeutic targets.
- Targeting L-selectin signaling offers potential for treating inflammatory conditions.
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