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Updated: May 15, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Aging signaling pathways and circadian clock-dependent metabolic derangements
Maria Florencia Tevy1, Jadwiga Giebultowicz, Zachary Pincus
1Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.
Trends in Endocrinology and Metabolism: TEM
|January 10, 2013
Summary
Aging disrupts the body's internal clock, affecting metabolism and potentially causing age-related diseases. Understanding these clock variations could reveal ways to delay the aging process.
Area of Science:
- Chronobiology
- Metabolism
- Aging Research
Background:
- The circadian clock regulates metabolism for optimal organism function.
- Aging is associated with declining circadian rhythms, metabolic homeostasis, and altered feeding behaviors.
- Disruptions in clock and nutrient-sensing networks may contribute to age-related diseases.
Purpose of the Study:
- To review the intricate connections between the circadian clock, metabolic health, and aging.
- To explore molecular mechanisms underlying age-related clock variations.
- To discuss implications for delaying the aging process.
Main Methods:
- Literature review of studies on circadian rhythms, metabolism, and aging.
- Analysis of data from various model organisms.
- Synthesis of current knowledge on molecular mediators.
Main Results:
- Circadian clock function declines with age across different species.
- Metabolic dysfunctions are linked to age-related alterations in circadian rhythms.
- Feeding behavior changes are observed in aged organisms with disrupted clocks.
Conclusions:
- The interplay between circadian clocks, metabolism, and aging is complex.
- Further research into molecular clock variations during aging may offer strategies for healthspan extension.
- Understanding these links is crucial for addressing age-related diseases.
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