Development of a novel two dimensional surface plasmon resonance sensor using multiplied beam splitting optics

Area of Science:

• Analytical Chemistry
• Optics and Photonics
• Biosensing Technology

Background:

• Surface Plasmon Resonance (SPR) is a label-free optical technique widely used for detecting molecular interactions.
• Conventional SPR sensors typically employ a single sensing point, limiting throughput and efficiency.
• Developing multi-point SPR systems is crucial for high-throughput screening and advanced analytical applications.

Purpose of the Study:

• To introduce a novel two-dimensional surface plasmon resonance (SPR) sensor system.
• To demonstrate the capability of multi-point sensing using a unique optical design.
• To evaluate the performance of the developed SPR sensor for quantitative analysis.

Main Methods:

• The core technology utilized multiplied beam splitting optics to achieve multi-point sensing.
• The system was designed to simultaneously measure nine distinct sensing points.
• Calibration curves were generated using sucrose solutions across a concentration range of 0-10%.

Main Results:

• The novel SPR sensor system successfully achieved simultaneous measurement at nine sensing points.
• Calibration curves for sucrose exhibited excellent linearity (correlation factor 0.996-0.998) in the 0-10% range.
• The system demonstrated high sensitivity with detection limits ranging from 1.98 × 10⁻⁶ to 3.91 × 10⁻⁵ Refractive Index Units (RIU).

Conclusions:

• The developed two-dimensional SPR sensor with a multi-point sensing region offers a significant advancement in sensing technology.
• The system's performance, including linearity and sensitivity, is comparable to conventional SPR sensors.
• This multi-point SPR system holds promise for applications requiring high-throughput and sensitive detection.