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Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration
1Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Italy.
Medical and Pediatric Oncology
|January 1, 1990
Abstract:
In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus. Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.