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FOXP3 genetic variant and risk of acute coronary syndrome in Chinese Han population

Qing Yang1, Yu Chen, Wei Yong

  • 1Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.

Cell Biochemistry and Function
|January 10, 2013
PubMed

Insights

Genetic variations in the Forkhead/winged helix transcription factor (FOXP3) gene may increase the risk of acute coronary syndrome (ACS). This study found a specific FOXP3 gene polymorphism associated with ACS in the Chinese Han population.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Human Genetics

Background:

  • Coronary artery disease (CAD) is a major global health concern, with acute coronary syndrome (ACS) representing its most severe manifestation.
  • Genetic factors are increasingly recognized for their role in the development of CAD and ACS.
  • Forkhead/winged helix transcription factor (FOXP3) gene polymorphisms have been linked to inflammatory conditions, suggesting a potential role in cardiovascular disease.

Purpose of the Study:

  • To investigate the association between FOXP3 gene polymorphisms and the susceptibility to ACS.
  • To examine the specific single nucleotide polymorphism (SNP) rs3761548 in the FOXP3 gene in relation to ACS risk.

Main Methods:

  • Genotyping of the FOXP3 gene SNP rs3761548 was performed using polymerase chain reaction-polyacrylamide gel electrophoresis.
  • The study included 226 patients diagnosed with ACS and 259 unrelated healthy individuals from the Chinese Han population.

Main Results:

  • A statistically significant association was observed between the FOXP3 gene single nucleotide polymorphism rs3761548 and ACS.
  • This finding suggests that the rs3761548 polymorphism may be a genetic risk factor for ACS in the studied population.

Conclusions:

  • The FOXP3 gene polymorphism rs3761548 is associated with an increased susceptibility to acute coronary syndrome in the Chinese Han population.
  • These results provide novel insights into the genetic underpinnings of ACS and highlight FOXP3 as a potential factor in its pathogenesis.

Keywords:
FOXP3acute coronary syndromegenetic polymorphisms

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