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Risk factors for preterm birth in five Maternal and Child Health hospitals in Beijing
Yun-Ping Zhang1, Xiao-Hong Liu, Su-Hong Gao
1Department of Gynecology and Obstetrics, Maternal and Child Health Hospital, Haidian District, Beijing, China. ypzhang7090@yahoo.com.cn
Insights
Preterm birth is linked to obesity, stress, and certain medical conditions. Prenatal care and a balanced diet significantly reduce the risk of preterm delivery in China.
Area of Science:
- Obstetrics and Gynecology
- Public Health
- Epidemiology
Background:
- Preterm birth (before 37 weeks) is a major cause of infant mortality and morbidity.
- Risk factors for preterm birth are well-researched in developed nations but less understood in developing countries like China.
- This study focuses on identifying preterm birth determinants in Beijing, China.
Purpose of the Study:
- To investigate the association between sociodemographic data, obstetric risk factors, and preterm birth.
- To identify independent risk factors and protective factors for preterm birth in the Chinese population.
- To provide evidence for informing local health and education policies.
Main Methods:
- A case-control study involving 1391 women with preterm birth and 1391 women with term delivery.
- Data collected through interviews within 48 hours of delivery.
- Statistical analysis using univariate and logistic regression to identify significant factors.
Main Results:
- Obesity, stressful life events, sexual activity, placenta previa, gestational diabetes mellitus, hypertensive disorders, prior preterm birth, and reproductive abnormalities were identified as independent risk factors.
- Living in urban areas, balanced diet, and receiving prenatal care were associated with a reduced likelihood of preterm birth.
- Inter-pregnancy interval and inherited diseases were not found to be risk factors.
Conclusions:
- Several key factors significantly increase the risk of preterm birth, including obesity, stress, and specific obstetric complications.
- Protective factors such as prenatal care and a balanced diet are crucial for reducing preterm birth rates.
- Findings can guide the development of targeted interventions and public health strategies in China.
Background:
Preterm birth, the birth of an infant prior to 37 completed weeks of gestation, is the leading cause of perinatal morbidity and mortality. Preterm infants are at greater risk of respiratory, gastrointestinal and neurological diseases. Despite significant research in developed countries, little is known about the causes of preterm birth in many developing countries, especially China. This study investigates the association between sciodemographic data, obstetric risk factor, and preterm birth in five Maternal and Child Health hospitals in Beijing, China.
Methods And Findings:
A case-control study was conducted on 1391 women with preterm birth (case group) and 1391 women with term delivery (control group), who were interviewed within 48 hours of delivery. Sixteen potential factors were investigated and statistical analysis was performed by univariate analysis and logistic regression analysis. Univariate analysis showed that 14 of the 16 factors were associated with preterm birth. Inter-pregnancy interval and inherited diseases were not risk factors. Logistic regression analysis showed that obesity (odds ratio (OR) = 3.030, 95% confidence interval (CI) 1.166-7.869), stressful life events (OR = 5.535, 95%CI 2.315-13.231), sexual activity (OR = 1.674, 95%CI 1.279-2.191), placenta previa (OR 13.577, 95%CI 2.563-71.912), gestational diabetes mellitus (OR = 3.441, 95%CI1.694-6.991), hypertensive disorder complicating pregnancy (OR = 6.034, 95%CI = 3.401-10.704), history of preterm birth (OR = 20.888, 95%CI 2.519-173.218) and reproductive abnormalities (OR = 3.049, 95%CI 1.010-9.206) were independent risk factors. Women who lived in towns and cities (OR = 0.603, 95%CI 0.430-0.846), had a balanced diet (OR = 0.533, 95%CI 0.421-0.675) and had a record of prenatal care (OR = 0.261, 95%CI 0.134-0.510) were less likely to have preterm birth.
Conclusions:
Obesity, stressful life events, sexual activity, placenta previa, gestational diabetes mellitus, hypertensive disorder complicating pregnancy, history of preterm birth and reproductive abnormalities are independent risk factors to preterm birth. Identification of remedial factors may inform local health and education policy.
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