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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Lymphatic Vessels and Lymph Transport

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Detailed Structure and Function of Lymph Nodes

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Related Experiment Video

Updated: May 15, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

[Lymphogranuloma venereum].

Daniela Vaňousová¹, Hana Zákoucká, Jaroslav Marvan

¹Dermatovenerologická Klinika 2. LF UK a Centrum pro Pohlavní Nemocnine Na Bulavce, Praha.

Casopis Lekaru Ceskych

|January 11, 2013

Summary

This summary is machine-generated.

Lymphogranuloma venereum, a Chlamydia trachomatis infection, is increasingly diagnosed in industrialized nations, primarily affecting men who have sex with men. Early diagnosis and treatment with doxycycline are crucial for managing this severe sexually transmitted disease.

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

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Last Updated: May 15, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

Infectious Diseases
Microbiology
Public Health

Context:

Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by specific serovars (L1-3) of Chlamydia trachomatis.
Historically endemic in tropical regions, LGV has seen a resurgence in industrialized countries, predominantly transmitted among men who have sex with men (MSM).
The first case in the Czech Republic was reported in 2011, highlighting its emergence in new geographical areas.

Purpose:

To discuss the epidemiology and clinical presentation of Lymphogranuloma venereum (LGV).
To emphasize the importance of including LGV in differential diagnoses for anorectal disorders.
To outline diagnostic and therapeutic strategies for LGV.

Summary:

LGV diagnosis relies on detecting Chlamydia trachomatis serovars L1-3 via polymerase chain reaction (PCR).
Differential diagnosis should consider inflammatory bowel diseases and other STIs like syphilis, HIV, and hepatitis C.
The recommended treatment is a three-week course of doxycycline.

Impact:

Increased awareness of LGV among healthcare providers can lead to earlier diagnosis and treatment.
Effective management of LGV can prevent severe anorectal complications and onward transmission.
Public health strategies may need adaptation to address the changing transmission patterns of this STI.