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Updated: May 15, 2026
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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Clinical and morphological correlations in acute ischemic stroke.
Anca Stefania Slujitoru1, Andreea Lorena Enache, Irina Lavinia Pintea
1University of Medicine and Pharmacy of Craiova, Romania. anca_slujitoru@yahoo.com
Summary
This study correlates clinical and histological findings in acute ischemic stroke patients. It reveals that the timing of death influences specific cellular changes and highlights universal microcirculation damage and complications like edema.
Area of Science:
- Neurology
- Pathology
- Histology
Background:
- Acute ischemic stroke presents heterogeneous brain injury involving all brain components.
- Understanding the chronology of lesion development and evolution is crucial for identifying prognostic factors.
Purpose of the Study:
- To establish clinical and histological correlations in acute ischemic stroke.
- To identify prognostic factors influencing patient outcomes.
Main Methods:
- Analysis of clinical and histopathological changes in 27 acute ischemic stroke cases (65-75 years old) with deaths within 30 days.
- Histological and immunohistochemical examination to identify neuronal, glial, and vascular damage.
- Correlation of clinical presentation with morphological findings.
Main Results:
- Neuronal damage included necrosis, ballooning, condensation, and red neurons in the ischemic penumbra.
- Vascular lesions featured capillary discontinuity and perivascular edema.
- Later death correlated with intense liquefactive necrosis, astrocyte gliosis, and phagocytosis; faster death correlated with intense apoptosis.
- Cerebral microcirculation modifications and complications (hemorrhagic transformation, edema) were observed universally, irrespective of post-stroke time.
Conclusions:
- Clinical and histopathological correlations in acute ischemic stroke provide insights into prognostic factors.
- The timing of neuronal death significantly impacts specific cellular responses.
- Cerebral microcirculation and major complications like edema are consistently affected post-stroke.
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