Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved...

Area of Science:

• Cardiology
• Biomarkers
• Heart Failure

Background:

• Diastolic dysfunction (DD) with preserved systolic function is a common complication of chronic ischemic heart disease, such as angina pectoris.
• Accurate diagnosis and risk stratification are crucial for managing these patients.

Purpose of the Study:

• To evaluate the utility of serum myeloperoxidase (MPO) levels in conjunction with electrocardiogram (ECG) and echocardiography for diagnosing and assessing risk in patients with DD and preserved systolic function.

Main Methods:

• The study included 91 patients diagnosed with DD and preserved systolic function due to stable angina.
• Diagnosis was confirmed via anamnesis, ECG, and echocardiography.
• Serum MPO levels were measured and correlated with echocardiographic parameters.

Main Results:

• A statistically significant correlation was observed between elevated serum MPO levels and echocardiographic findings indicative of DD.
• The combined assessment of ECG, echocardiography, and MPO levels proved effective in stratifying patient risk.

Conclusions:

• The triad of ECG, echocardiography, and MPO assessment enables early detection of DD with preserved systolic function.
• Increased circulating MPO levels serve as a valuable biomarker for diagnosis and risk assessment in this patient population.