Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Anatomical Terminology01:20

Anatomical Terminology

Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automatic Placement Within a Hierarchical Clinical Decision Support Terminology.

Studies in health technology and informatics·2026
Same author

Semantic Relations: Extending SNOMED CT and Solor.

Applied clinical informatics·2025
Same author

Machine learning-based risk scores are associated with conversion to dementia in Veterans.

Journal of Alzheimer's disease : JAD·2025
Same author

Identifying Probable Dementia in Undiagnosed Black and White Americans Using Machine Learning in Veterans Health Administration Electronic Health Records.

Big data and cognitive computing·2025
Same author

Retrieval Augmented Generation: What Works and Lessons Learned.

Studies in health technology and informatics·2025
Same author

The Semantic Clinical Artificial Intelligence (SCAI) Chatbot: Preliminary Usability Testing.

Studies in health technology and informatics·2025
Same journal

Sensitivity Analyses of a Scoring System for a Contraception Decision Aid.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Improving electronic health record processing of large language models via retrieval-augmented generation: A case study on dietary supplements.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Developing a User-Centered Mobile Application Prototype: Bridging Lower-Limb Fracture Care from Skilled Nursing Facility and Back to the Community.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

KERAP: A Knowledge-Enhanced Reasoning Approach for Accurate Zero-shot Diagnosis Prediction Using Multi-agent LLMs.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Automating Adjudication of Cardiovascular Events Using Large Language Models.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Predictive Factors and State-Level Barriers to Postpartum Birth Control Usage in the United States: Insights from PRAMS Phase 8.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Synonym, topic model and predicate-based query expansion for retrieving clinical documents.

Qing T Zeng1, Doug Redd, Thomas Rindflesch

  • 1VA Salt Lake City, UT, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|January 11, 2013
PubMed
Summary
This summary is machine-generated.

This study improved clinical document retrieval using three query expansion methods. A topic model-based approach enhanced recall and F-measure, outperforming other techniques for finding relevant clinical information.

More Related Videos

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications
09:20

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Published on: February 23, 2019

Related Experiment Videos

Last Updated: May 15, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications
09:20

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Published on: February 23, 2019

Area of Science:

  • Medical Informatics
  • Information Retrieval
  • Natural Language Processing

Background:

  • Retrieving relevant documents from large clinical data warehouses is challenging.
  • Effective information retrieval is crucial for clinical decision-making and research.

Purpose of the Study:

  • To develop and evaluate three distinct query expansion methods for clinical document retrieval.
  • To compare the performance of synonym expansion, topic modeling, and predicate database methods against a baseline.

Main Methods:

  • Implemented synonym expansion using selected vocabularies.
  • Trained a topic model on clinical documents to identify related terms.
  • Utilized a predicate database from Medline abstracts for term identification.

Main Results:

  • All three query expansion methods improved average recall and average F-measure compared to the baseline.
  • Average precision and precision at 10 decreased across all expansion methods.
  • The topic model-based query expansion demonstrated superior performance in recall and F-measure.

Conclusions:

  • Query expansion techniques can enhance the retrieval of clinical documents.
  • Topic modeling offers a promising approach for improving recall and F-measure in clinical information retrieval.
  • Further research may be needed to balance precision and recall trade-offs.