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Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 15, 2026

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
09:36

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

Published on: August 29, 2012

Genetic mouse models to study blood-brain barrier development and function.

Fabien Sohet1, Richard Daneman

  • 1UCSF Department of Anatomy, 513 Parnassus Ave HSW1301, San Francisco, 94117, California, USA. Fabien.sohet@ucsf.edu.

Fluids and Barriers of the CNS
|January 12, 2013
PubMed
Summary
This summary is machine-generated.

Genetic mouse models are crucial for understanding the blood-brain barrier (BBB), a key regulator of substance transport in the central nervous system (CNS). This review covers current and potential genetic tools for studying the BBB.

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Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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Related Experiment Videos

Last Updated: May 15, 2026

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
09:36

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

Published on: August 29, 2012

Isolation of Primary Murine Brain Microvascular Endothelial Cells
08:14

Isolation of Primary Murine Brain Microvascular Endothelial Cells

Published on: November 14, 2014

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
06:19

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

Published on: October 20, 2023

Area of Science:

  • Neuroscience
  • Physiology
  • Genetics

Background:

  • The blood-brain barrier (BBB) is a vital physiological structure regulating substance exchange between blood and central nervous system (CNS) neural tissue.
  • Understanding BBB development, regulation in health, and disease response is critical for neurological research.

Purpose of the Study:

  • To review genetic mouse models used in studying the BBB.
  • To discuss existing genetic tools available for BBB research.
  • To identify potential future genetic tools that could advance BBB studies.

Main Methods:

  • Analysis of existing literature on genetic mouse models for BBB research.
  • Cataloging current genetic tools applicable to BBB studies.
  • Identifying gaps and proposing future genetic tool development.

Main Results:

  • Several genetic mouse models have been instrumental in elucidating BBB functions.
  • A range of genetic tools are currently available to investigate BBB components and pathways.
  • The development of novel genetic tools could significantly enhance our understanding of the BBB.

Conclusions:

  • Genetic mouse models and tools are indispensable for advancing BBB research.
  • Further development of genetic technologies will accelerate discoveries regarding BBB regulation and disease mechanisms.